Fast one-pot synthesis of 1,8-dioxo-decahydroacridine derivatives using sulfonic acid functionalized LUS-1 and the study on their antimicrobial activities
Authors
Abstract:
Mesoporous silica LUS-1 (Laval University Silica) was successfully functionalized by propyl sulfonic acid and was used as a recyclable catalyst for the synthesis of acridine-1,8-diones via a pseudo four component reaction of aromatic aldehydes, dimedone and ammonium acetate (or anilines). The excellent yields, short reaction time, simple work-up procedure, and environmentally friendly conditions are advantages of this method. All synthesized compounds were screened for antimicrobial and antifungal activities. Only compound 3e exhibited activity against Bacillus subtilis.
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Journal title
volume 6 issue 4
pages 369- 375
publication date 2016-09-01
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